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. Author manuscript; available in PMC: 2019 Jul 11.
Published in final edited form as: Pediatr Res. 2018 May 2;83(6):1200–1206. doi: 10.1038/pr.2018.45

Figure 1.

Figure 1.

Weights and survival analysis in plp homozygous (plp hom) and md male rats following treatment with saline or clemastine (CLE) (daily dose 10–30 mg/kg) for a total of 21 days. Clemastine slowed down weight gain in plp hom (a) but not md male rats (b). In fact, md rats seemed to thrive better on clemastine 30 mg/kg during their third week of life. Survival analysis (c, d) revealed no difference in survival between plp hom untreated rats and those treated with clemastine 30 mg/kg/day for 21 days (CLE 30). Similarly, no difference in survival was achieved by treatment of md male rats with clemastine 30 mg/kg/day over 21 days as opposed to untreated md male rats (log-rank (Mantel–Cox) test).