Skip to main content
. Author manuscript; available in PMC: 2019 Jul 11.
Published in final edited form as: Pediatr Res. 2018 May 2;83(6):1200–1206. doi: 10.1038/pr.2018.45

Figure 3.

Figure 3.

MBP immunohistochemistry reveals fragmented myelin and myelin islands in the brains of plp hom and md male rats. Dense immunostaining for MBP is shown in the brainstem (a) and the cerebellar white matter (d) of a 21-day-old control rat. In b, conglomerates of multidirectional fragmented myelin fibers (myelin islands, arrows) are shown in the brainstem of a plp hom rat treated with clemastine, daily dose30 mg/kg over 21 days. In c, another example of fragmented MBP immunopositive fibers within the pyramidal tract is shown in the same rat as in b. (e) A light micrograph from the cerebellum of a male md rat treated with saline for 21 days. (f) A plastic section stained with toluidine blue from the spinal cord of a male md rat treated with clemastine, daily dose 30 mg/kg for 21 days. A single myelinated fiber is identified (arrow). Bars = 100 μm (a–d); 500 μm (e); 50 μm (f).