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. Author manuscript; available in PMC: 2019 Jul 31.
Published in final edited form as: Oncogene. 2019 Jan 31;38(21):3989–4001. doi: 10.1038/s41388-019-0713-x

Figure 2. Evolutionary conservation of E3 ligases and DUBs regulating mTOR signaling.

Figure 2.

The presence of mTOR signaling components (middle), identified regulating E3 ligases (left) and DUBs (right) in indicated four species (human, mouse, c. elegans and fruit fly) are indicated by dots with distinct colors. Conservation information is obtained from NCBI-homologene, genecards, KEGG pathway, uniport and literature search. Absence of any dot means either not conserved or never examined and reported.