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. 2012 Oct 31;32(44):15476–15488. doi: 10.1523/JNEUROSCI.2429-12.2012

Figure 1.

Figure 1.

The effect of OXT on the induction of LTP in the CA1 region of rat hippocampal slices. A, Summary of experiments showing pairing one train of 1 s TS at 100 Hz with OXT (1 μm) application induced LTP of fEPSPs in slices from female rat dorsal hippocampus. Pairing TS with vehicle induced only a transient increase in synaptic strength. B, Summary of experiments showing the effect of OXT treatment on the induction of LTP by one train of TS in slices from female rat ventral hippocampus. C, Summary of experiments showing the effect of OXT treatment on the induction of LTP by one train of TS in slices from male rat dorsal hippocampus. D, Summary histogram depicting the effect of oxytocin on the induction of LTP by one train of TS in slices from female or male hippocampus. The magnitudes of LTP were measured 110–120 min after TS. E, Summary of experiments showing the effect of OXT treatment on the induction of LTP by one train of TS in the presence of PTX (100 μm) in slices from female rat dorsal hippocampus. Representative traces of fEPSPs were taken at the time indicated by number. Dash lines show level of baseline. The total number of animals examined is indicated by n in parenthesis. Data are represented as mean ± SEM. *p < 0.05 compared with vehicle-treated group.