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. 2012 Oct 31;32(44):15476–15488. doi: 10.1523/JNEUROSCI.2429-12.2012

Figure 2.

Figure 2.

OXTR-coupled PLC signaling pathway mediates the enhancement of LTP by OXT. A, Summary of experiments showing pretreatment of hippocampal slices with OXTR antagonist L-371257 (1 or 3 μm) dose-dependently blocked OXT (1 μm)-induced enhancement of LTP. B, Summary of experiments showing the enhancement of OXT on LTP was blocked by pretreatment of the hippocampal slices with the PLC inhibitor U73122 (10 μm) but not by its inactive analog U73343 (10 μm). C, Summary histogram depicting the effect of L-371257, U73122, and U73343 on OXT-induced enhancement of LTP in slices from female dorsal hippocampus. The magnitudes of LTP were measured 110–120 min after TS. Representative traces of fEPSPs were taken at the time indicated by number. Dash lines show level of baseline. The total number of animals examined is indicated by n in parenthesis. Data are represented as mean ± SEM. *p < 0.05 compared with vehicle-treated group.