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. 2012 Oct 31;32(44):15476–15488. doi: 10.1523/JNEUROSCI.2429-12.2012

Figure 3.

Figure 3.

LTP induced by pairing one train of TS with OXT application requires de novo protein synthesis. A, Summary of experiments showing pretreatment of hippocampal slices with protein synthesis inhibitors, cycloheximide (Chx, 50 μm) or anisomycin (Ani, 20 μm) blocked OXT (1 μm)-induced enhancement of LTP. B, Summary of experiments showing the effect of transcription inhibitor actinomycin D (Act-D, 25 μm) on OXT-induced enhancement of LTP in slices from female dorsal hippocampus. C, Summary of experiments showing the enhancement of OXT on LTP was blocked by pretreatment of the hippocampal slices with rapamycin (Rap, 200 nm) but not by its inactive analog ascomycin (Asc, 200 nm). D, Summary histogram depicting the effect of cycloheximide, anisomycin, actinomycin D, rapamycin, and ascomycin on OXT-induced enhancement of LTP in slices from female dorsal hippocampus. The magnitudes of LTP were measured 110–120 min after TS. Representative traces of fEPSPs were taken at the time indicated by number. Dash lines show level of baseline. The total number of animals examined is indicated by n in parenthesis. Data are represented as mean ± SEM. *p < 0.05 compared with vehicle-treated group.