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. 2012 Oct 31;32(44):15476–15488. doi: 10.1523/JNEUROSCI.2429-12.2012

Figure 5.

Figure 5.

OXT stimulates PKMξ synthesis in hippocampal CA1 region. A, Representative immunoblot and summary histogram showing OXT (1 μm) time-dependently induces increases in PKMξ expression in the whole tissue lysates of hippocampal CA1 region. B, Representative immunoblot and summary histogram showing the effect of vehicle, OXT (1 μm), one train of TS, KCl (50 mm), and three trains of TS treatment on the expression of PKMξ in the whole tissue lysates of hippocampal CA1 region. C, Representative immunoblot and summary histogram showing OXT (1 μm)-induced increases in PKMξ expression were blocked by pretreatment with cycloheximide (Chx, 50 μm) or anisomycin (Ani, 20 μm) but not by actinomycin D (Act-D, 25 μm). D, Representative immunoblot and summary histogram showing pretreatment of the synaptoneurosomes with rapamycin (Rap, 200 nm) but not ascomycin (Asc, 200 nm) blocked OXT (1 μm)-induced increases in PKMξ synthesis. The total number of experiments is indicated by n in parenthesis. Data are represented as mean ± SEM. *p < 0.05 compared with vehicle-treated group.