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DHPG-evoked currents are increased in Purkinje cells from GluRδ2ho-4J/ho-4J mice. A, Typical traces recorded from wild-type or GluRδ2ho-4J/ho-4J Purkinje cells evoked by GABA (1 mm), DHPG (20 and 50 μm), or CPCCOEt (200 μm) plus DHPG (50 μm). B, Quantified peak amplitude of the GABA- and DHPG-evoked responses. C, Quantified area under the curve of GABA- and DHPG-evoked responses. Error bars indicate SEM. Statistical significance with respect to GluRδ2+/+ (t test). *p < 0.05.
