Table 1.
Genotype | Tis21WT | Tis21KO | Ptch1+/−/Tis21WT | Ptch1+/−/Tis21+/− | Ptch1+/−/Tis21KO |
---|---|---|---|---|---|
Medulloblastoma (%) | 0 (0.0) | 0 (0.0) | 118 (25.35) | 41* (75.93) | 60* (80.00) |
Average latency (weeks) | — | — | 20.09 ± 1.7 | 25.46 ± 1.5† | 25.57 ± 1.3† |
No. of mice analyzed | 40 | 42 | 71 | 54 | 75 |
aThe five genotypes refer to the progeny of breedings between Patched1 heterozygotes and Tis21 knock-out mice; all mouse genotypes are in the same genetic background, having been cross-mated for at least six generations.
*p < 0.0001 versus Ptch1+/−/Tis21WTgroup (χ2 test).
†p < 0.05 versus Ptch1+/−/Tis21WT group (Student's t test).