Figure 9.

Adult SVZ neurogenic niche and its modulation by the Nogo-A/NgR1 interaction. A, At the level of the LW of the lateral ventricle, NSCs divide to generate transit amplifying progenitors (TAPs), which, in turn, give rise to neuroblasts. B, The Nogo-66 domain on neuroblast membranes interacts with NgR1⁺ NSCs and limits both their proliferation and neurogenic activity. Conversely, the N terminal of Nogo-A, containing the Δ20 domain, regulates neuroblast migration through the interaction with an uncharacterized mediator that leads to the activation of the Rho/ROCK pathway.