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Intrahippocampal ANI and CHX infusions induce dramatic and significant decreases in both protein synthesis and hippocampal activity. Infusions of 50 μg of ANI in 0.5 μl (A) and 20 μg of CHX in 0.5 μl (B) significantly decreased the incorporation of radiolabeled amino acids and CSD RMS in the ipsilateral HPC, while vehicle (PBS) infusions (C) had no effect on either parameter. Error bars indicate SEM.
