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. 2012 Nov 28;32(48):17477–17491. doi: 10.1523/JNEUROSCI.1939-12.2012

Figure 9.

Figure 9.

The ratio of p-TH/TH but not total TH is reduced in the VTA of cKO mice. A, C, Immunofluorescence images illustrating a TH/Ser(40)-Ph-TH double-immunolabeling experiment performed in the SNc (A) or VTA (C) of CTRL and cKO P35 mice. B, D, The p-TH/TH ratio per TH+ neuron was reduced in the VTA (D) (p = 0.047; Mann–Whitney rank sum test; n = 12 for control; n = 13 for cKO) but not in the SNc (B) (p = 0.74; Mann–Whitney rank sum test; n = 10 for control; n = 11 for cKO) of cKO mice. E, F, There was no difference in total TH immunoreactivity per dopaminergic neuron in the SNc (E) (p = 0.74; Mann–Whitney rank sum test; n = 10 for control; n = 11 for cKO) or the VTA (F) (p = 0.089; Mann–Whitney rank sum test; n = 12 for control; n = 13 for cKO) of cKO mice. n represents the number of slices analyzed on three animals of each genotype.