Table 1.

Number of entries and latency to enter the two compartments of the light–dark box in control and PRS rats bilaterally infused with vehicle or CGP53432 plus LY341495 into the ventral hippocampus

	Number of entries	Latency to enter (s)
CONT/vehicle
Light compartment	5.5 ± 0.6	46 ± 9.0
Dark compartment	5.9 ± 0.6	28 ± 9.5
PRS/vehicle
Light compartment	5.2 ± 1.0	228 ± 31*
Dark compartment	4.7 ± 0.9	9.9 ± 1.8
CONT/ CGP + LY
Light compartment	5.2 ± 0.9	49 ± 7.3
Dark compartment	5.5 ± 0.8	22 ± 3.2
PRS/CGP + LY
Light compartment	6.3 ± 0.4	35 ± 3.8
Dark compartment	6.8 ± 0.4	18 ± 3.2

Data were obtained from the same control (CONT) and PRS rats of Figure 5B; see legend for details on treatments with CGP53432 and LY341495. Values are means ± SEM of six rats per group.

*p < 0.01 versus latency to enter the light compartment in all other groups.