Table 2.

EPM data of control and PRS rats bilaterally infused with vehicle or CGP53432 plus LY341495 into the ventral hippocampus

	CONT/vehicle	PRS/vehicle	CONT/CGP + LY	PRS/CGP + LY
Number of entries into the open arm	5.5 ± 0.6	2.3 ± 0.5a	5.0 ± 0.4	4.3 ± 0.2
Number of entries into the closed arm	8.2 ± 0.5	7.0 ± 0.6	11 ± 1.7	9.2 ± 0.7
Number of crossings through the center	13 ± 0.8	11 ± 1.7	13 ± 1.2	12 ± 1.0
Episodes of head dips	11 ± 1.5	4.8 ± 1.4b	14 ± 1.4	9.7 ± 1.3c
Rearing episodes	10 ± 1.5	8.8 ± 0.5	8.5 ± 1.6	10 ± 0.9
Latency to enter the open arm	6.2 ± 1.4	71 ± 25d	5.9 ± 1.4	14 ± 2.9
Latency to enter the closed arm	37 ± 4.2	1.9 ± 0.5e	57 ± 15	12 ± 4.9

Data were obtained from the same control (CONT) and PRS rats of Figure 5B; see legend for details on treatments with CGP53432 and LY341495. Values are means ± SEM of six rats per group.

^ap < 0.01 versus all other groups;

^bp < 0.01 versus CONT/vehicle and CONT/CGP + LY, and p < 0.05 versus PRS/CGP + LY;

^cp < 0.05 versus CONT/CGP + LY and PRS/vehicle;

^dp < 0.01 versus all other groups; and

^ep < 0.05 versus CONT/vehicle and p < 0.01 versus Cont/CGP + LY. CONT, controls.