Figure 2.

Repetitive magnetic stimulation induces a long-lasting increase in excitatory synaptic transmission in vitro. A, Sample traces of AMPA-R-mediated mEPSCs from control and stimulated hippocampal CA1 pyramidal neurons. B, Cumulative distributions of AMPA-R-mediated mEPSC amplitudes and inter-mEPSC intervals. C, D, A significant increase in mean mEPSC amplitudes (C) was observed between 2 and 6 h pms, while mEPSC frequencies (D) were found to be increased at all time points recorded after magnetic stimulation (n = 14–27 neurons per group, with up to 5 recorded neurons per culture and 5–11 cultures per group; 97 neurons total). Statistical comparisons were performed with pooled nonstimulated age- and time-matched controls (indicated by dashed line). Means ± SEM are shown in this and the following figures (*p < 0.05; **p < 0.01; ***p < 0.001).