Figure 5.

Respiratory patterns of late-stage Mecp2^−/y mice in response to treatment of CRHR1 blocker antalarmin. A, Representative whole-body plethysmographic recordings of Mecp2^−/y mice during sleep at late stage in a large chamber under control conditions and 40 min after administration of antalarmin (Anta; 10 mg/kg i.p.). B, Population data showing apneas per minute and coefficient of variation for Mecp2^−/y mice during quiet wakefulness and sleep at late stage in large plethysmographic chambers with or without antalarmin pretreatment. n = 9 for WT, n = 5 for Mecp2^−/y; ^NSp ≥ 0.05, ⁺p < 0.05, *p < 0.01, and ^#p < 0.001 between two groups.