Figure 7.

Respiratory rhythm generated by perfused in situ WHBPs of WT and Mecp2^−/y mice at early and late stages. Integrated (∫) and raw phrenic (Phr) nerve recordings from a P59 WT male (Mecp2^+/y) (A), P36 Mecp2^−/y (early-stage) (B), P44 Mecp2^−/y (late stage) (C), and same WHBP preparation (D) from after application of CRHR1 antagonist antalarmin (1 mg/100 ml) (C). E, Population data showing the numbers of apneas per minute. n = 5, 4, 5, and 3 for WT, early-stage Mecp2^−/y, later-stage Mecp2^−/y before antalarmin, and later-stage Mecp2^−/y in the presence of antalarmin, respectively. ^NSp ≥ 0.05, ⁺p < 0.05, and *p < 0.01 between the two groups.