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. 2019 Jul 4;10:1545. doi: 10.3389/fimmu.2019.01545

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Copyright © 2019 Timmermans, Souffriau and Libert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glucocorticoid receptor gene and protein. (A) Genomic structure of the glucocorticoid receptor (GR) gene. (B) Alternative splice and translation-initiation variants of the GR protein. (C) Structure of the GR protein consisting of an N-terminal domain (NTD), DNA-binding domain (DBD), a hinge region (H), and a ligand-binding domain (LBD), with a focus on the two zinc-fingers of the DBD and the GR^Dim mutation (A458T in human, A465T in mouse). Identified post-translational modifications of the GR are indicated in the black circles. Regions important in GR function are indicated below the protein. AF, Activation function; NES, Nuclear Export Signal; NLS, Nuclear Localization Signal; NRS, Nuclear Retention Signal; P, phosphorylation; S, sumoylation; U, ubiquitination; N, nitrosylation; O, oxidation; A, acetylation.