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. 2019 Jul 4;10:1545. doi: 10.3389/fimmu.2019.01545

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Copyright © 2019 Timmermans, Souffriau and Libert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glucocorticoid receptor chaperone complex and maturation. (A) After glucocorticoid receptor (GR) translation an Hsp70-Hsp40-GR complex is formed in the cytoplasm. (B) A subsequent ADP-dependent Hsp70 change induces the binding of Hop. (C) Hop induces the binding of Hsp90. (D) After Hsp90 binding to Hop, Hsp70, and Hsp40 are released from the chaperone complex and replaced by p23 and FKPB51. The GR has now matured into a high affinity complex. (E) After binding of glucocorticoids FKBP51 is replaced by FKBP52, which is necessary for the transport of the GR to the nucleus.