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. 2019 Jul 11;7:112. doi: 10.1186/s40478-019-0766-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Mechanism of ADCC bystander killing. a Perforin immunofluorescence of CHO-AQP4 and CHO-null cocultures after pre-coating with AQP4-IgG and incubation NK cells, as in Fig. 2b, with controls including control IgG and NK cells, and AQP4-IgG alone. White filled arrows indicate perforin on AQP4-expressing CHO cells, white open arrows show perforin on CHO-null cells. b Time-lapse imaging of coculture of CHO-AQP4 cells (labeled green with cell tracker) and CHO-null cells, pre-incubated for 30 min AQP4-IgG, then at indicated times after NK cell addition (for explanation see text and Additional file 2: Video S2)