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. 2019 Jul 11;3:13. doi: 10.1186/s41512-019-0059-4

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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Forest plot for prognostic effect of progesterone on cancer specific survival in endometrial cancer, with summary results for univariate and multivariate meta-analysis. The multivariate meta-analysis of cancer specific survival and progression-free survival used the approach of Riley et al. to handle missing within study correlations, through restricted maximum likelihood estimation [33]. Heterogeneity was similar in both univariate and multivariate meta-analyses (I² = 70%)