Table 3.
Cytokines/inflammatory markers according to spine osteoporosis status
| Markers | Osteoporotic | Osteopenic | Healthy | F-value | P-value |
|---|---|---|---|---|---|
| (n = 13) | (n = 34) | (n = 39) | |||
| IL-1β (pg/ml) | 7.22(17.59) | 2.06(4.88) | 1.52(4.21) | 2.670 | 0.075 |
| IFN-α2 (pg/ml) | 35.28(48.19) | 9.96(18.95) | 18.42(26.63) | 3.783 | 0.027 |
| IFN-γ (pg/ml) | 153.38(222.32) | 50.67(58.72) | 57.91(73.24) | 4.956 | 0.009 |
| TNF-α (pg/ml) | 2.01(2.70) | 1.83(3.72) | 3.19(6.02) | 0.795 | 0.455 |
| MCP-1 (pg/ml) | 221.36(100.46) | 176.66(43.13) | 200.73(55.68) | 3.000 | 0.055 |
| IL-6 (pg/ml) | 3.22(4.29) | 3.14(11.26) | 3.09(10.61) | 0.001 | 0.999 |
| IL-8 (pg/ml) | 23.85(42.34) | 11.19(11.84) | 10.66(14.99) | 2.220 | 0.115 |
| IL-10 (pg/ml) | 4.62(15.67) | 0.57(1.52) | 0.75(1.95) | 2.261 | 0.111 |
| IL-12p70 (pg/ml) | 6.47(17.03) | 1.86(5.74) | 0.48(1.36) | 3.128 | 0.049 |
| IL-17A (pg/ml) | 102.40(227.62) | 41.75(79.92) | 31.11(45.72) | 2.303 | 0.106 |
| IL-18 (pg/ml) | 153.45(72.70) | 133.21(69.18) | 144.98(51.66) | 0.600 | 0.551 |
| IL-23 (pg/ml) | 103.40(173.69) | 56.60(91.14) | 42.84(55.70) | 1.970 | 0.146 |
| IL-33 (pg/ml) | 13.88(37.44) | 0.79(3.32) | 2.83(11.19) | 3.147 | 0.048 |
| CRP (μg/ml) | 0.75(1.07) | 1.39(1.36) | 2.04(2.05) | 3.219 | 0.044 |
| Ferritin (μg/L) | 149.46(116.16) | 124.45(94.57) | 156.29(103.72) | 0.890 | 0.415 |
IL Interleukin, IFN Interferon, MCP Monocyte chemoattractant protein, CRP C-reactive protein. Osteoporosis status was according to WHO classification [25]. Variables are reported as mean values with their standard deviation (SD). Number of participants (n). Significant values are in bold text