Fig. 1.

Monthly wheel running parameters over the course of the 8-month exercise intervention period. a The number of rotations performed by each mouse was recorded with computer software in 1-minute bins during each exercise session. The total number of rotations performed was summed during each session as a measure of running volume. b Running speed (rotations/minute) was calculated by averaging the number of rotations performed in 1-min bins that were not counted as a “break,” essentially averaging the number of rotations performed per minute when the number of rotations performed in that bin was greater than five. c Breaks per hour was calculated to determine the number of 1-min bins per hour during which the mouse was not running. A “break” was a 1-min bin in which the animal performed less than five wheel rotations. #p < 0.05 versus Tg-SwDI 1 h; $p < 0.05 versus Tg-SwDI 3 h