Figure 1.

Aβ42-induced release of ATP from cultured primary astrocytes and U373 astrocyte cell lines. A, ATP release was measured after treatment of the primary astrocytes with Aβ42 (2 or 4 μm) for 3 h. ATP was significantly released in astrocytes treated with Aβ42 (4 μm). B, ATP was significantly released from U373 cells treated with Aβ42 (2 or 10 μm) for 3 h. Extracellular ATP in the conditioned media was measured by luciferin-luciferase assay. Values are means of three independent experiments ± SD. Statistical significance was tested by one-way ANOVA followed by a Tukey's multiple-comparison test. **p < 0.01 versus vehicle (control) group. Vcl, Vehicle.