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. 2012 Feb 29;32(9):3081–3087. doi: 10.1523/JNEUROSCI.6357-11.2012

Figure 5.

Figure 5.

Effects of ATP alone or in combination with PPADS on Aβ42-mediated reduction of synaptic molecules. A, Primary hippocampal neurons treated with Aβ42 (2 μm) and pretreated with or without PPADS (50 μm) for 30 min were exposed to Aβ42 combined with ATP for 48 h. Representative Western blots were detected with antibodies targeting NR2A, PSD-95, NR1, and tubulin. Tubulin was used as a loading control. The arrow indicates a specific band of PSD-95. B, C, Quantification of NR2A (B) and PSD-95 (C). Statistical significance was tested by one-way ANOVA followed by a Tukey's multiple-comparison test. *p < 0.05 versus vehicle (Veh) group; #p < 0.05 versus Aβ42-treated group; &p < 0.05 versus Aβ42 combined with ATP-treated group.