Figure 2.

Increased expression of bioactive caspase-1 and IL-1β is reduced in the injured spinal cord of P2X₄-KO mice. A, Representative immunoblots of caspase-1, IL-1β, and IL-18 after SCI. B–D, Densitometric analysis indicates that both caspase-1 (B) and IL-1β (C) are decreased in the P2X₄-KO when compared with WT animals. Levels of IL-18 (D) are not altered in P2X₄-KO animals when compared with WT animals (n = 5 per group). Data are presented as mean ± SEM. *p < 0.05 compared with P2X₄-KO animals. ^†p < 0.05 compared with sham animals.