Figure 4.

Ara-C infusion decreases the production of adult-born neurons. a, b, Ara-C decreases cell proliferation measured by the number of BrdU-IR cells (a) and the number of Dcx-IR cells without vertical dendrites (b). c, In contrast, Ara-C spares mature Dcx-labeled cells with vertical dendrites. aCSF: n = 10; AraC 0.2: n = 8; AraC 0.6: n = 5; AraC 1: n = 8. The lowest efficient dose of Ara-C was used in subsequent experiments. ***p < 0.001 compared with aCSF-infused animals. Error bars indicate SEM.