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. 2019 Apr 1;8(4):509–521. doi: 10.1039/c9tx00005d

Table 1. Interaction definitions for binary mixtures of bioactives based on the fitting of the copula model.

  Condition Definition
For all (n1, n2) θ: Min(n1, n2) ≤ θ ≤ Max(n1, n2) DA, DI if θ ≈ 1
θ: θ < Min(n1, n2) Antagonism, DI if θ ≈ 1
θ: Max(n1, n2) < θ ≤ 1 Synergy/DI
θ: 1 ≤ Max(n1, n2) < θ Synergy