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. 2012 Mar 28;32(13):4553–4561. doi: 10.1523/JNEUROSCI.6010-11.2012

Figure 3.

Figure 3.

Effects of BDNF Val66Met alone and stratified for COMT Val158Met carrier status on cortical plasticity using PAS25. A, BDNF Val/Val carriers (triangles, dashed line) exhibited larger MEP sizes than BDNF Met carriers (circles, gray line) after LTP induction relative to baseline (pre), most pronounced at post 0 (ANOVARM, p = 0.117). B, In COMT Met/Met carriers only, BDNF Val/Val genotype was significantly associated with an increase in MEP sizes pre vs post 0 compared with BDNF Met carriers, indicating higher PAS-induced plasticity in the combined BDNF Val/Val + COMT Met/Met genotype group (p = 0.01). C, No differences were found within COMT Val carriers. Bars indicate SEM. *p < 0.01 according to ANOVARM post hoc t test.