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. 2012 Apr 11;32(15):5024–5038. doi: 10.1523/JNEUROSCI.6366-11.2012

Figure 4.

Figure 4.

Angiogenin mediates neuroprotection through a paracrine pathway in primary mixed motoneuron cultures. A, Scheme depicting generation of rhAng-conditioned medium (cMed, 100 ng/ml) to test paracrine protection. MTT assay (B) and direct counts (C) of motoneuron survival in primary mixed motoneuron cultures treated with AMPA (50 μm), AMPA and cMedAng, or AMPA (50 μm) and cMed from denatured rhAng-treated cultures (cMed denat. Ang; *p ≤ 0.05; mean ± SD; data from n = 4–6 cultures in 3 independent experiments).