Fig. 6.
Analysis of spine configurations. In addition to total spines, we also evaluated spine density based on three specific spine configurations on a per neuron basis in control (n = 6, 30 total neurons analyzed) and bTBI (n = 6, 31 total neurons analyzed) mice. (A) We examined T-type (thin) spines and saw no significant differences (p = .695). (B) M-type (mushroom) spines showed a significant increase in M-type spine density in bTBI mice (p = .003). (C) S-Type (stubby) spines showed small increases in density in bTBI, though this was not statistically significant (p = .289). A single control neuron outlier was removed from analysis of S-Type spines.