Figure 5.

Effect of 8-pCPT-cGMP on the light-evoked Ca²⁺ response in cone terminals. A, Light-evoked Ca²⁺ responses in three representative cone terminals (marked by color-coded ROIs) before, during, and after wash-out of 8-pCPT-cGMP (50 μm, bath application). Time points given from application start (in brackets: from beginning of wash-out). B, Quantification of the responses of all seven cone terminals recorded in the experiment shown in A. C, Summary of the 8-pCPT-cGMP effect on light-evoked Ca²⁺ responses for n = 17 terminals (from 4 retinas), with each symbol representing a cone (averages ± SD are given next to each symbol column). For the timing parameters (t_rise, t_decay), values are only plotted for cones (n = 3), of which the response was not completely suppressed by 8-pCPT-cGMP (Wilcoxon signed test for paired samples, **p < 0.01; all others, not significant).