Table 1.

Summary of pharmacological effects on light-evoked Ca²⁺ response in cone terminals

	n	Rbase	ΔR	RA	trise (ms)	tdecay (ms)
8-pCPT-cGMP
Control	17	1.07 ± 0.13	−0.13 ± 0.07	−0.13 ± 0.08	195 ± 78	333 ± 432
Drug	17	1.85 ± 0.25**	−0.02 ± 0.02**	−0.01 ± 0.00**	89 ± 61a	951 ± 365a
Wash-out	17	1.91 ± 0.91**	−0.17 ± 0.11	−0.17 ± 0.16	184 ± 210	642 ± 882
Zaprinast
Control	15	0.90 ± 0.13	−0.13 ± 0.06	−0.18 ± 0.10	228 ± 104	797 ± 369
Drug	15	1.38 ± 0.33**	−0.36 ± 0.28**	−0.46 ± 0.31**	375 ± 196b*	932 ± 490b
Wash-out	11	1.23 ± 0.10**	−0.25 ± 0.06**	−0.21 ± 0.08	132 ± 20*	121 ± 156**
SNAP
Control	19	0.97 ± 0.13	−0.31 ± 0.10	−0.32 ± 0.13	196 ± 88	180 ± 103
Drug	19	0.80 ± 0.07**	−0.15 ± 0.05**	−0.15 ± 0.07**	194 ± 57	180 ± 240
Wash-out	19	0.81 ± 0.05**	−0.18 ± 0.05**	−0.16 ± 0.07**	206 ± 133	111 ± 113**
ODQ
Control
Group 1	11	1.13 ± 0.22	−0.25 ± 0.16	−0.25 ± 0.12	171 ± 22	380 ± 379
Group 2	5	1.36 ± 0.13	−0.37 ± 0.05	−0.27 ± 0.07	133 ± 21	360 ± 193
Drug
Group 1	11	1.53 ± 0.26**	−0.38 ± 0.11*	−0.43 ± 0.14*	190 ± 77	532 ± 391
Group 2	5	1.29 ± 0.11	−0.35 ± 0.05	−0.35 ± 0.09	169 ± 44	105 ± 27
Wash-out
Group 1	7	1.24 ± 0.13	−0.21 ± 0.11*	−0.17 ± 0.10*	215 ± 80	176 ± 127
Group 2	5	1.18 ± 0.09	−0.26 ± 0.06	−0.21 ± 0.04	139 ± 19	474 ± 842

Parameters are presented as mean ± SD. Significance levels are determined using the Wilcoxon signed test for paired samples (always versus control condition,

**p < 0.01,

*p < 0.05; all others, not significant. n is number of cells

^an = 3;

^bn = 11.