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Discrete activity-dependent changes of NFs in the signaling network during LTD. A, LTD occurrence (LTD > 10%) promotes a small shift in the power of NFs of PKC and large shifts for the powers of NFs of ERK and cPLA2, calculated for single runs of the model. B, Correlation between the powers of stochastic fluctuations is strong only between ERK and cPLA2. In all panels, LTD was induced by Ca2+ pulses of 1–60 s and 0.5–3.5 μmol.L−1.
