Figure 2.
Confirmation of 5,7-DHT lesions. 5,7-DHT lesions were confirmed my measuring 5-HT concentration (A) and by 5-HT transporter binding using 11C-DASB autoradiography (B). Rats with lesions of the DRN exhibited decreased [5-HT] in the DL CPu, whereas MRN-lesioned animals had lower [5-HT] in the hippocampus. Animals with dual lesions of the DRN and MRN had decreased [5-HT] in both regions measured (A). The same pattern was observed with serotonin transporter binding. Animals with DRN lesions exhibited decreased binding in the DRN and CPu, whereas decreased binding was observed in the MRN and HC in MRN-lesioned animals. Animals with dual lesions had lower binding in all regions examined. *p < 0.01, **p < 0.001.