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. 2012 Jul 11;32(28):9574–9581. doi: 10.1523/JNEUROSCI.1196-12.2012

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Copyright © 2012 the authors 0270-6474/12/329574-08$15.00/0

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Figure 4. — Effect of DBS on 5-HT function. STN-DBS decreased expression of the immediate early gene zif268 in both HAL- and VEH-treated rats in the DRN (A) and MRN (B), whereas EPN-DBS had no effect. Similarly, STN-DBS significantly decreased 5-HT release in the DL CPu in both HAL- and VEH-treated rats (C). This decrease occurred immediately after DBS onset and persisted for up to 36 min after DBS offset. DBS application is indicated from 60 min to 120 min. Indication of statistical significance is omitted for clarity. EPN-DBS had no effect on 5-HT levels. N = 7–8/group. *p < 0.05.