Figure 5.

Effect serotonergic pharmacomanipulation of DBS efficacy. DBS suppressed VCMs for the 60 min of DBS application in all HAL-treated groups (A, B, E, F). After 60 min of STN-DBS, VCM levels were higher after fluoxetine pretreatment than after saline pretreatment (A). There were no differences between saline and fluoxetine pretreatment on VCMs during STN-DBS in VEH-treated rats (C). Fluoxetine pretreatment did not alter the efficacy of EPN-DBS (B, D). VCM levels were greater during STN-DBS when rats had been pretreated with fenfluramine (E) and DOI (F), although these differences did not achieve statistical significance. N = 8/group (HAL-treated groups) and N = 6/group (VEH-treated groups).