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. 2012 May 23;32(21):7178–7190. doi: 10.1523/JNEUROSCI.0008-12.2012

Figure 6.

Figure 6.

DA activity-dependent increase in DRD2L insertion depends on DRD2L endocytosis and Rab11-dependent recycling endosomes. A, Hypertonic sucrose abolishes DA activity-dependent DRD2L recycling. B, Arrestin-binding mutant of DRD2 abolishes DA activity-dependent DRD2 recycling. C, DA stimulation enhances DRD2L recycling through Rab11-dependent recycling endosomes. −DA, pH-DRD2L without DA stimulation; +DA, pH-DRD2L with DA stimulation; +DA +Sucrose, pH-DRD2L with DA stimulation in the presence of hypertonic sucrose; +DA +IYIV_4A, pH-DRD2L IYIV_4A mutant with DA stimulation; +DA +Rab4DN, pH-DRD2L with DA stimulation in the presence of dominant-negative mutant of Rab4; +DA +Rab11DN, pH-DRD2L with DA stimulation in the presence of dominant-negative mutant of Rab11. Asterisks denote statistical significance compared to the control group. n.s., Not significant.