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. 2012 May 23;32(21):7178–7190. doi: 10.1523/JNEUROSCI.0008-12.2012

Figure 7.

Figure 7.

Rab4 and Rab11 differentially regulate DRD2L function. A, Rab4DN reduces steady-state surface expression of DRD2L. Surface, Surface staining of pH-DRD2L; Total, total level of pH-DRD2L; group 1, control; group 2, Rab4DN; group 3, Rab11DN. B, Rab11DN inhibits DRD2L re-sensitization following DA stimulation. Group 1, Control; group 2, control plus DA; group 3, Rab4DN plus DA; group 4, Rab11DN plus DA. C, A model for the roles of Rab4 and Rab11 in regulation of DRD2L recycling. Under basal conditions, internalized DRD2L constitutively recycles from sorting endosomes to the PM via the Rab4-dependent route. Rab11 contributes little to constitutive DRD2L recycling. In contrast, when stimulated with DA, the Rab4-dependent fast recycling remains fully functional, but DRD2L recycling and functional resensitization occur primarily via the Rab11-dependent recycling pathway. Asterisks denote statistical significance compared to the control group. n.s., Not significant.