Figure 4.

The proinflammatory microenvironment in diseased biopsy samples with interstitial fibrosis may direct MAIT cells toward a more activated state. (A–C) Levels of (A) TNF-α, (B) IL-1β, and (C) IL-18 in the supernatant of dissociated healthy kidney tissue (n=10) and diseased biopsy samples stratified on the basis of the absence (n=11) or presence of interstitial fibrosis (n=19). Values for individual donors are presented; horizontal bars represent medians, with interquartile range also presented. *P<0.05, Kruskal–Wallis test with Dunn’s post-test.