Table 3.
Histomorphometry analyses of bones from GHS rats fed KCl, KCit, CTD, or KCit+CTD
| Histomorphometry | KCl | KCit | KCl+CTD | KCit+CTD |
|---|---|---|---|---|
| Undecalcified static | ||||
| OV/BV, % | 0.80±0.6 | 0.67±0.4 | 0.27±0.40 | 0.21±0.21 |
| OS/BS, % | 0.11±0.09 | 0.07±0.04 | 0.03±0.04 | 0.02±0.02 |
| Osteoid width, mm | 2.00±1.04 | 2.26±0.54 | 2.33±0.54 | 2.77±1.38 |
| Dynamic | ||||
| MS/BS, % | 0.11±0.07 | 0.2±0.08 | 0.1±0.05a | 0.16±0.08 |
| MAR, μm/d | 1.53±0.58 | 1.58±0.32 | 1.26±0.62 | 1.47±0.57 |
| BFR/BS, μm3/μm2 per d | 0.18±0.16 | 0.32±0.15 | 0.15±0.10 | 0.24±0.14 |
| Decalcified | ||||
| Oc.S, mm | 0.33±0.26 | 0.2±0.22 | 0.23±0.15 | 0.29±0.2 |
| Oc.S/BS, % | 0.05±0.04 | 0.03±0.03 | 0.03±0.02 | 0.05±0.04 |
| N.Oc | 4.70±3.9 | 4±4.5 | 4.2±3.7 | 4.2±2.9 |
| N.Oc/BS (1/mm) | 0.68±0.54 | 0.38±0.29 | 0.49±0.35 | 0.6±0.5 |
| N.Oc/Oc.s (1/mm) | 14.71±2.5 | 15.8±3.8 | 13.76±4.9 | 13.48±2.2 |
There were no significant differences comparing all groups to KCl alone or comparing KCl+CTD to KCit+CTD. Results are mean±SD for eight to ten rats per group. There were no significant differences comparing KCl+CTD to KCit+CTD. KCl, potassium chloride; OV/BV, % osteoid volume/bone volume; OS/BS, % osteoid surface/bone surface; MS/BS, mineralized surface/bone surface; MAR, mineral apposition rate; BFR/BS, bone formation rate/bone surface; Oc.S, osteoclast surface; Oc.S/BS, osteoclast surface/bone surface; N.Oc, number of osteoclasts; N.Oc/BS, number of osteoclasts/bone surface; N.Oc/Oc.s, number of osteoclasts/osteoclast surface.
a
P<0.05 versus KCit alone.