Table 1.
Mouse models with an IgA nephropathy–like disease manifestation
| Model | Glomerular IgA Deposits (Species) | Total IgA Levels in Blood | GFR | Proteinuria | Hematuria | Glomerular Pathology |
|---|---|---|---|---|---|---|
| Present study1 | ||||||
| AID wild-type mice | ++ (Human) | ↑ about fivefold | Normal | None | None | Mild mesangial expansion and C3 deposition |
| AID-deficient mice | +++ (Human) | ↑ about 50-fold | Reduced | None | None | Mesangial expansion and C3 deposition |
| Mice expressing human IgA1 and CD89 | +++ (Human) | ↑ >100-fold | Mildly reduced | + | ++ | Mesangial expansion and C3 deposition |
| High-IgA mice | +++ (Mouse) | ↑ up to fourfold | Reduced | + | None | Mesangial expansion and C3 deposition |
| β-1,4-galactosyl-transferase–deficient mice | ++ (Mouse) | ↑ up to tenfold | No data | ++ | + | Mesangial expansion and C3 deposition |
| CD37-deficient mice | +++ (Mouse) | ↑ up to 15-fold | Normal | None | None | Mesangial expansion and hypercellularity; no data on C3 |
| BAFF transgenic mice | +++ (Mouse) | ↑ up to 50-fold | ESRD at 17 mo | ++ | +++ | Mesangial matrix expansion; no data on C3; little C4 |
| Uteroglobin-deficient mice | +++ (Mouse) | No data | No data | No data | +++ | Mesangial matrix expansion and C3 deposition |
| LIGHT transgenic mice | +++ (Mouse) | ↑ 30- to 40-fold | No data | ++ | + | Mesangial matrix expansion and C3 deposition |
| MBP20 peptide fusion protein | +++ (Mouse) | No data | No data | (+) | ++ | Mesangial matrix expansion and proliferation and C3 deposition |
| Monoclonal IgA from Peyer patch hybridomas of vomitoxin-exposed mice | ++ (Mouse) | ↑ two- to four-fold | No data | No data | + | Normal mesangium, C3 deposition |
AID, activation-induced cytidine deaminase. Modified from ref. 9, with permission.