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. Author manuscript; available in PMC: 2019 Jul 11.
Published in final edited form as: Adv Exp Med Biol. 2017;1042:43–59. doi: 10.1007/978-981-10-6955-0_2

Fig. 2.

Fig. 2

While the profiles of activated replication origins are similar within cell line, specific replication origin chosen by cells within that population varies in location and replication time. Most origins exhibit flexible initiation patterns, where the specific origins activated differ between cells. When such flexible origins remain “dormant” and do not initiate replication, they replicate passively from adjacent replication forks