Figure 2.

The functional cycle of Era as an essential GTPase. The crystal structures of Era are shown based on superimposed GTPase domains, including Era:GNP:RNA (PDB entry 3IEV) and Era:GNP (PDB entry 1WF3) sharing the closed conformation, and apo-Era (PDB entry 1EGA) and Era:GDP (PDB entry 3IEU) sharing the open conformation. The GTPase domain, the linker and the KH domain are shown in white, red and orange, respectively. Switches I and II and the GXXG and variable loops are highlighted in blue, and the α9 helix, βa and β7 strands, and linker are highlighted in red. The GNP and RNA molecules are colored in green, and the Mg²⁺ ion in magenta. Highly simplified representation of each structure is composed of a rectangle and an ellipse. This figure was adopted from Reference [12] with revisions and additions.