Table 4. Diagnostic performance of K-RAS mutation, ACR TIRADS and combination.
Diagnostic Modality | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95%CI) | NPV (95%CI) | AC (95%CI) |
---|---|---|---|---|---|
K-RAS mutation in FNA sample | 25.0 (5.5–57.2) | 86.2 (68.3–96.1) | 42.9 (16.5–74.1) | 73.5 (66.0–79.9) | 68.3 (51.9–81.9) |
TIRADS 11 | 83.3 (51.6–97.9) | 24.1 (10.3–43.5) | 31.3 (24.7–38.6) | 77.8 (45.8–93.5) | 41.5 (26.3–57.9) |
TIRADS 22 | 75.0 (42.8–94.5) | 72.4 (52.8–87.3) | 52.9 (36.4–68.8) | 87.5 (71.9–95.0) | 73.2 (57.1–85.8) |
Combination 1 | 91.7 (61.5–99.8) | 20.7 (8.0–39.7) | 32.4 (27.1–38.1) | 85.7 (44.6–97.8) | 41.5 (26.3–57.9) |
Combination 2 | 83.3 (51.6–97.9) | 58.6 (38.9–76.5) | 45.5 (33.5–57.9) | 89.5 (69.8–96.9) | 65.9 (49.4–79.9) |
1 TR4 was taken as the diagnostic threshold.
2 TR5 was taken as the diagnostic threshold.
Combination 1 = K-RAS mutation +TIRADS 1; Combination 2 = K-RAS mutation +TIRADS 2. PPV (positive predictive value); NPV (negative predictive value); AC (accuracy)