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. 2019 Jul 11;14(7):e0219383. doi: 10.1371/journal.pone.0219383

Table 4. Diagnostic performance of K-RAS mutation, ACR TIRADS and combination.

Diagnostic Modality Sensitivity (95% CI) Specificity (95% CI) PPV (95%CI) NPV (95%CI) AC (95%CI)
K-RAS mutation in FNA sample 25.0 (5.5–57.2) 86.2 (68.3–96.1) 42.9 (16.5–74.1) 73.5 (66.0–79.9) 68.3 (51.9–81.9)
TIRADS 11 83.3 (51.6–97.9) 24.1 (10.3–43.5) 31.3 (24.7–38.6) 77.8 (45.8–93.5) 41.5 (26.3–57.9)
TIRADS 22 75.0 (42.8–94.5) 72.4 (52.8–87.3) 52.9 (36.4–68.8) 87.5 (71.9–95.0) 73.2 (57.1–85.8)
Combination 1 91.7 (61.5–99.8) 20.7 (8.0–39.7) 32.4 (27.1–38.1) 85.7 (44.6–97.8) 41.5 (26.3–57.9)
Combination 2 83.3 (51.6–97.9) 58.6 (38.9–76.5) 45.5 (33.5–57.9) 89.5 (69.8–96.9) 65.9 (49.4–79.9)

1 TR4 was taken as the diagnostic threshold.

2 TR5 was taken as the diagnostic threshold.

Combination 1 = K-RAS mutation +TIRADS 1; Combination 2 = K-RAS mutation +TIRADS 2. PPV (positive predictive value); NPV (negative predictive value); AC (accuracy)