Table 1. Clinical parameters of patients stratified by stiffness.
All values are given as median and range. BMI: Body-mass index, AST: aspartate aminotransferase, ALT: alanine aminotransferase; GGT: γ–glutamyl transferase, CAP: Controlled attenuation parameter.
| HIV (all) | HIV patients without significant fibrosis (Stiffness <7.1 kPa) |
HIV patients with significant fibrosis (Stiffness ≥7.1) |
P-value | |
|---|---|---|---|---|
| Total number of patients n (%) | 116 (100) | 101 (87.1) | 15 (12.9) | n.s |
| Age (years) | 47.3 (24–72) | 46.5 (24–72) | 53.9 (45–67) | 0.001 |
| Gender (male/female) | 96/20 | 85/16 | 11/4 | n.s |
| BMI (kg/cm2) | 23 (17–61) | 23 (17–61) | 25 (19–30) | n.s |
| AST (U/L) | 23 (9–93) | 23 (9–65) | 26 (16–93) | 0.002 |
| ALT (U/L) | 29 (10–99) | 29 (10–84) | 31 (13–99) | n.s |
| GGT (U/L) | 45 (17–302) | 45 (17–302) | 55.0 (26–228) | n.s |
| Bilirubin (mg/dl) | 0.45 (0.15–4.5) | 0.45 (0.15–4.6) | 0.39 (0.27–2.3) | n.s |
| Stiffness Fibroscan (kPa) | 4.8 (2–14.8) | 4.6 (2.0–6.8) | 8.2 (7.1–14.8) | <0.001 |
| Steatosis CAP (dB/m) | 233.5 (100–378) | 231.0 (100–378) | 243.0 (101–351) | n.s |
| APRI Score | 0.2 (0.1–1.4) | 0.2 (0.1–0.9) | 0.3 (0.2–1.4) | <0.001 |
| PRO-C3 (ng/ml) | 9.8 (5–40) | 9.4 (5–24) | 13.8 (8.-40) | <0.001 |
| PRO-C4 (ng/ml) | 274 (126–1023) | 262 (126–1023) | 309.9 (128–510) | n.s |
| C3M (ng/ml) | 8.6 (5–20) | 8.6 (5–20) | 9.1 (7–17) | n.s |
| C4M (ng/ml) | 57.5 (30–130) | 56.9 (30–123) | 63.5 (39–130) | n.s |