Table 5. Negative predictive value, sensitivity, and specificity for studies with follow-up.
| Study authors | SP, n | TP, n | SN, n | FN, n | NPV, % 95% CI |
Sensitivity, % 95% CI |
Specificity, % 95% CI |
|---|---|---|---|---|---|---|---|
| Almenar Latorre | 11 | 4 | 1521 | 0 | 100.0 99.9–100.0 |
100.0 51.0–100.0 |
99.5 99.6–99.8 |
| Berninger | n/a | 57 | n/a | 0 | n/a | 100.0 93.7–100.0 |
n/a |
| Calcutt | 1633 | 121 | 174187 | 10 | 100.0 100.0–100.0 |
92.4 86.5–95.8 |
99.1 99.1–99.2 |
| Calevo | 41 | 20 | 32217 | 0 | 100.0 100.0–100.0 |
100.0 83.9–100.0 |
99.9 99.9–100.0 |
| Cao-Nguyen | n/a | 24 | n/a | 2 | n/a | 92.3 75.9–97.9 |
n/a |
| De Capua | 1536 | 24 | 18164 | 1 | 100.0 100.0–100.0 |
96.0 80.5–99.3 |
92.3 91.9–92.7 |
| Ng | 37 | 3 | 1027 | 0 | 100.0 99.6–100.0 |
100.0 43.9–100.0 |
96.8 95.6–97.7 |
| O'Connor | 525 | 12 | 11213 | 1 | 100.0 100.0–100.0 |
92.3 66.7–98.6 |
95.6 95.2–96.0 |
| Watkin | n/a | 32 | n/a | 4 | n/a | 88.9 74.7–95.6 |
n/a |
| Wessex | 392 | 22 | 20887 | 2 | 100.0 100.0–100.0 |
91.7 74.2–97.7 |
98.3 98.1–98.4 |
CI: confidence intervals; FN: false negatives; n/a: not given or could not be calculated; NPV: negative predictive value: SN: screen negatives; SP: screen positives; TP: true positive