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. 2019 Jul 11;14(7):e0219774. doi: 10.1371/journal.pone.0219774

Fig 1. Relative importance of mutation statuses of oncogenes for predicting drug activity against cancer cell lines.

Fig 1

(A) Gini impurity indices calculated for entire data set consisting of 225 drugs and 990 cancer cell lines. The 50 most important oncogenes are shown. (B) The top-ranking oncogenes for each individual drug were computed as those whose relative importance is >2 standard deviations above the average oncogene importance for that drug. The 20 oncogenes that are top-ranking for the greatest number of drugs are shown. Gini impurity indices for the mutation statuses were computed from random forest classification models at an IC50 activity cutoff of 1 μM.