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. 2019 Jul 11;14(7):e0219610. doi: 10.1371/journal.pone.0219610

Table 2. Top 10 process networks and GO cellular processes to MCF-7 and MDA-MB-468 treated with Roundup.

MCF-7- Roundup
Process Network FDR GO Process FDR
Cell cycle_S phase 1.90E-18 Cell cycle 3.943E-41
DNA damage_Checkpoint 5.411E-14 Cellular metabolic process 1.067E-40
Cell cycle_Core 2.114E-11 Mitotic cell cycle 2.625E-40
Cell cycle_G1-S 4.673E-07 Cell cycle process 9.226E-38
Cell cycle_G2-M 5.459E-07 Cellular macromolecule metabolic process 1.555E-36
DNA damage_DBS repair 3.781E-06 Cellular response to stress 1.652E-36
Cell cycle_Mitosis 9.690E-06 Nucleobase-containing compound metabolic process 1.100E-35
DNA damage_MMR repair 4.794E-05 Organic cyclic compound metabolic process 3.301E-35
Apoptosis_Apoptotic nucleus 4.794E-05 Mitotic cell cycle process 7.841E-35
Cell cycle_Meiosis 2.837E-04 Nucleic acid metabolic process 1.242E-34
MDA-MB-468- Roundup
Process Network FDR GO Process FDR
Cell cycle_S phase 5.484E-05 Cellular metabolic process 1.153E-16
DNA damage_Checkpoint 4.621E-03 Primary metabolic process 1.170E-15
Reproduction_FSH-beta signaling pathway 1.915E-02 Cellular macromolecule metabolic process 3.385E-15
Cell cycle_G1-S 1.915E-02 Metabolic process 3.178E-14
Cell cycle_G2-M 1.915E-02 Organic substance metabolic process 1.328E-13
Apoptosis_Apoptotic nucleus 2.516E-02 Cellular process 3.276E-13
Protein folding_Response to unfolded proteins 2.516E-02 Nitrogen compound metabolic process 7.355E-13
Cytoskeleton_Intermediate filaments 2.516E-02 Mitotic cell cycle 7.355E-13
Development_Blood vessel morphogenesis 3.680E-02 Regulation of cellular metabolic process 6.546E-12
Proliferation_Negative regulation of cell proliferation 3.680E-02 Cell cycle 1.088E-11