Figure 2.

1-[¹¹C]l-lactate is a suitable tracer to study cerebral lactate oxidation. A, Measured radioactivity concentration in the brain (open circles), model fit (black line), and arterial input curve (gray line). The inset displays the residuals of the fitting to a one-tissue compartment model. The absence of any distribution bias supports the adequacy of the applied one-tissue compartment model. B, Fraction of native radiolabeled lactate over 40 min after intravenous injection of 1-[¹¹C]l-lactate in blood. The filled circles represent data points from baseline experiments (n = 7) performed to characterize the radiotracer, and the solid line is the corresponding fit of a biexponential curve.